Effects of a novel vaccine(DNA-protein nanoparticle) on melanoma immunotherapy in mice by enhancing dendritic cell activation

【Author】

Hao Wang;Xiaoxia Zhang;Jiaqing Zhao;Mei Han;Jing Xue;

【Abstract】

<正>It has always being a crucial impediment of cancer therapeutic vaccine,"how to break out of the immune tolerance for the tumor?"Single virus-based DNA vaccine or subunit antigen vaccine,could induce limited effective anti-tumor immunity.However,cationic combination DNA with protein as a whole vaccine,whether or not,can generate more effectiveness,remains elusive.In the present study,we

【Keywords】

vaccine;melanoma;immunotherapy;elusive;immunity;DNA;subunit;enhancing;cationic;vaccination;

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