Integrated nanovaccine with microRNA-148a inhibition reprograms tumor-associated dendritic cells by modulating miR-148a/DNMT1/SOCS1 axis

【Author】

Lanlan Liu;Yifan Ma;Lintao Cai;

【Abstract】

<正>Immunosuppressive tumor-associated dendritic cells(TADCs)are potential targetsfor cancer therapy.However,their poor responsiveness to toll-like receptor(TLR)stimulation is a major obstacle for achieving successful cancer immunotherapy.In the present study,we reported a dysregulated mi R-148a/DNMT1/SOCS1 axis as a unique mechanism for dampened TLR stimulation in TADCs.The results showed that aberrantly elevated mi R-148a in bone marrow derived-TADC(BM-TADC)abolished

【Keywords】

SOCS;microRNA;stimulation;modulating;immunotherapy;obstacle;suppressing;elevated;immunity;modulated;

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