Targeting CLEC9A can deliver antigen to human CD141+ DC for recognition by both CD4+ and CD8+ T cells

【Author】

Kirsteen Tullett;Ingrid Leal Rojas;Yoshihito Minoda;Peck Tan;Jian-Guo Zhang;Corey Smith;Rajiv Khanna;Ken Shortman;Irina Caminschi;Mireille Lahoud;Kristen Radford;

【Abstract】

<正>Targeting vaccine antigens(Ag)to the dendritic cells(DC)that initiate cytotoxic T lymphocyte(CTL)responses is an attractive strategy for tumor immunotherapy or viral clearance.The mouse CD8+DC-lineage and their human CD141+DC equivalents cross-present Ag and initiate CTL responses.The C-type lectin-like receptor CLEC9A,that senses dead cells and facilitates Ag cross-presentation,is specifically expressed

【Keywords】

Targeting;initiate;deliver;immunotherapy;lymphocyte;attractive;clearance;cytotoxic;lectin;presentation;

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