Versican promotes differentiation of IL-10-producing tumor dendritic cells(DCs) in cancer

【Author】

Jun Diao;Hontao Gu;Michael Tang;Jun Zhao;Mark cattral;

【Abstract】

<正>DC dysfunction is considered a major factor in the development of tumor immune escape.We recently reported that TLR2 ligands in the tumor microenvironment(TME)promote the generation of IL-10-producing DCs(Tang et al).Versican,an ECM proteoglycan,is upregulated in many cancers and is a known TLR2 ligand.In this study,we investigated the role of versican as a mediator of DC dysfunction.We

【Keywords】

producing;proteoglycan;mediator;escape;currently;blocked;intracellular;conditioned;immunotherapy;cultured;

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