Use of dendritic cells loaded with MAGED4 recombinant protein to generate cytotoxic T lymphocytes against glioma

【Author】

Qing-Mei Zhang;Shui-Qing Bi;Bin Luo;Ying-Ying Ge;Jun Fu;Xi-Sheng Li;Ya Peng;Fang Chen;Nong-Wei Xia;Guo-Rong Luo;Shao-Wen Xiao;Xiao- Xun Xie;

【Abstract】

<正>Introduction:MAGED4 is overexpressed in glioma whilst restricted expression in normal tissues.Here,we examine the immunogenicity of MAGED4 in glioma to determine its potential as an immunotherapeutic target.Methods:Dendritic cells(DCs)was generated from adherent PBMCs of a HLA-A2+healthy donor and identified by flow cytometry.MAGED4-specific CTLs targeting

【Keywords】

glioma;restricted;cytometry;targeting;cytotoxic;donor;loaded;expressing;instead;ELISPOT;

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