CTLA-4+breast cancer cells inhibit dendritic cells function and the reverse effect of CTLA-4 blocking therapy

【Author】

Xi Chen;Shengnan Hao;Qianqian Shao;Zhonghua Zhao;Ying He;Wenjuan GaO;Haiting Mao;

【Abstract】

<正>Cytotoxic T lymphocyte-associated antigen 4(CTLA-4)expressed by T lymphocytes is traditionally known as a potent immunoregulatory molecule that down-regulates T-cell activation and thus inhibits anti-tumor immune response.Antibodies that specifically blocking the binding of CTLA-4 with its ligands can enhance immune response.This study analyzed the expression of CTLA-4 on human breast cancer cells(BCCs)and CTLA-4 highly expressed BCCs(MDA-MB-231)were

【Keywords】

blocking;lymphocyte;potent;inhibit;traditionally;cytokine;specifically;suppressed;suppression;themselves;

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