Generation of protective immunity against Orientia tsutsugamushi infection by immunization of zinc oxide nanoparticle combined with ScaA antigen

【Author】

Nam-Hyuk Cho;Na-Young Ha;Prashant Sharma;Hyun Ah Cho;Chan-Ki Min;Hong-il Kim;Nguyen Thi Hai Yen;Ik-Sang Kim;Myung-Sik Choi;Young Keun Kim;

【Abstract】

<正>Zinc oxide nanoparticle(ZNP)is a biocompatible metal oxide which has been applied for various biomedical fields.Here,we investigated potential usage of ZNP as an antigen carrier for vaccine development by combining with high affinity peptide to ZNP.A novel Zinc oxide-binding peptide(ZBP),FPYPGGDA,with high affinity to ZNP(K_a=2.26×10~6 M~(-1))was isolated from a random peptide library and fused with a

【Keywords】

affinity;immunity;protective;library;vaccine;Zinc;usage;fused;biomedical;adjuvant;

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