Inflammatory plasma proteins classifiers predict disease severity and response to therapy in patients with LCH

【Author】

Karen Phaik Har Lim;Daniel Zinn;Howard Lin;Brooks Scull;Albert Shih;Miguel Cantu;Harshal Abhyankar;Rikhia Chakraborty;Stephen Simko;Tricia Peters;Sergio Lira;Kenneth McClain;Miriam Merad;Chris Tsz-Kwong Man;Carl Allen;

【Abstract】

<正>Langerhans cell histiocytosis(LCH)is a myeloproliferative disorder with complex clinical manifestations.No histologic features of LCH lesions correlate with clinical outcomes.We hypothesize that function of differentiated CD207~+,including interactions with recruited activated lymphocytes,results in plasma protein profiles that reflect disease burden and tissue-specific DC-lymphocyte interactions.Plasma

【Keywords】

histiocytosis;Langerhans;lymphocyte;severity;correlate;differentiated;relapse;burden;hypothesize;osteopontin;

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