Lin ZHANG, Zhong-Xin ZHAO Department of Neurology, Changzheng Hospital, Shanghai 200003, China
Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synaptic contacts. They could induce the change of the synaptic plasticity to regulate various adaptation reactions, and change the cognitive behaviors. So we presume that if some cognitive behavior are damaged, synapsins would be changed as well. This gives us a new recognition of better diagnosis and therapy of cognitive disorder desease.
synapsin; synaptic plasiticity; cognitive behavior; cognitive disorder
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