The impact of synapsins on synaptic plasticity and cognitive behaviors


Lin ZHANG, Zhong-Xin ZHAO Department of Neurology, Changzheng Hospital, Shanghai 200003, China


Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synaptic contacts. They could induce the change of the synaptic plasticity to regulate various adaptation reactions, and change the cognitive behaviors. So we presume that if some cognitive behavior are damaged, synapsins would be changed as well. This gives us a new recognition of better diagnosis and therapy of cognitive disorder desease.


synapsin; synaptic plasiticity; cognitive behavior; cognitive disorder


To explore the background and basis of the node document

Springer Journals Database

Total: 33 articles

  • [1] Wang T, Xie K, Lu B, Neurotrophins promote maturation of developing neuremuscular synapses, J Neurosci, The Journal of Neuroscience (The Journal of Neuroscience)
  • [2] Finkbeiner S, Neurotrophins and the synapse, Neuroscientist, The Neuroscientist (The Neuroscientist)
  • [3] Patterson SL, Grover LM, Schwartzkroin PA, et al, Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs, Neuron, Neuron (Neuron)
  • [4] Schiebler W, Jahn R, Doucet JP, et al, Characterization of synapsin Ⅰ binding to small synaptic vesicles, J Biol Chem, Journal of Biological Chemistry (Journal of Biological Chemistry)