Smoking and Serum Lipid Profiles in Schizophrenia

【Author】

Hui-Mei An;Yun-Long Tan;Shu-ping Tan;Jing Shi;Zhi-Ren Wang;Fu-De Yang;Xu-Feng Huang;Jair C.Soars;Thomas R.Kosten;Xiang-Yang Zhang;Beijing Hui Long Guan Hospital,Peking University;Centre for Translational Neuroscience, School of Medicine,Illawarra Health and Medical Research Institute,University of Wollongong;Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston;Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine;

【Institution】

Beijing Hui Long Guan Hospital,Peking University;Centre for Translational Neuroscience, School of Medicine,Illawarra Health and Medical Research Institute,University of Wollongong;Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston;Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine;

【Abstract】

Schizophrenia is associated with a high prevalence of cigarette-smoking and abnormal lipid profiles. The purpose of this study was to determine whether the profiles differ between schizophrenic smokers and non-smokers and whether the lipid profiles are related to psychopathological symptoms. Serum lipid profiles were measured in 130 male inpatients with DSM-IV-defined schizophrenia:104 smokers and 26 non-smokers. Symptoms were assessed using the Positive and Negative Syndrome Scale(PANSS). Our results showed that positive PANSS symptoms were fewer in smokers than in non-smokers, while the negative symptoms were fewer in those who smoked more cigarettes. Total protein and globulin levels were significantly lower in the smokers than in the non-smokers.However, there was no significant difference in total cholesterol, triglycerides, high-density lipoprotein cholesterol(HDL-c), low-density lipoprotein cholesterol,apolipoprotein A1,or apolipoprotein B between the smokers and non-smokers. However, the PANSS positive subscale had a significant negative correlation with the HDL-c levels(a protective factor) in the smokers but not in the non-smokers. Our findings suggest that schizophrenic patients who smoke have fewer psychotic symptoms, but contrary to expectation, smoking does not alter lipid profile levels.

【Keywords】

Schizophrenia;;Nicotine;;Cigarette smoking;;Lipid profiles;;Symptoms

References

To explore the background and basis of the node document

Springer Journals Database

Total: 22 articles

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