Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease

【Author】

Ning Song;Junxia Xie;Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University;Institute of Brain Science and Disease, Qingdao University;

【Institution】

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University;Institute of Brain Science and Disease, Qingdao University;

【Abstract】

<正>Parkinson’s disease(PD)is recognized as the second most common neurodegenerative disorder after Alzheimer disease.Although a fascinating 200-year journey of research has revealed the multifaceted nature of PD[1,2],its fundamental features are the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc)and depletion of dopamine(DA)in the striatum.Iron accumulates in normal brains with aging.Such

【Keywords】

In;Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease;and;Dopamine;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 9 articles

  • [1] Song Li;Weidong Le;Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University;Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases,The First Affiliated Hospital, Dalian Medical University;Collaborative Innovation Center for Brain Science,The First Affiliated Hospital, Dalian Medical University;, Milestones of Parkinson's Disease Research: 200 Years of History and Beyond, Neuroscience Bulletin,
  • [2] Roberta J Ward;;Fabio A Zucca;;Jeff H Duyn;;Robert R Crichton;;Luigi Zecca, The role of iron in brain ageing and neurodegenerative disorders, Lancet Neurology,
  • [3] Przedborski S, The two-century journey of Parkinson disease research, Nat Rev Neurosci, Nature Reviews Neuroscience (Nature Reviews Neuroscience)
  • [4] Jiang H;Wang J;Rogers J;Xie J, Brain iron metabolism dysfunction in Parkinson''s disease, Mol Neurobiol, Molecular Neurobiology (Molecular Neurobiology)

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