Brain-wide Mapping of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum

【Author】

Xiaomeng Wang;Hongbin Yang;Libiao Pan;Sijia Hao;Xiaotong Wu;Li Zhan;Yijun Liu;Fan Meng;Huifang Lou;Ying Shen;Shumin Duan;Hao Wang;Department of Neurobiology and Department of Neurosurgery of The Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of the Ministry of Health of China,NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University School of Medicine;

【Institution】

Department of Neurobiology and Department of Neurosurgery of The Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of the Ministry of Health of China,NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University School of Medicine;

【Abstract】

The laterodorsal tegmentum(LDT) is a brain structure involved in distinct behaviors including arousal,reward, and innate fear. How environmental stimuli and top-down control from high-order sensory and limbic cortical areas converge and coordinate in this region to modulate diverse behavioral outputs remains unclear.Using a modified rabies virus, we applied monosynaptic retrograde tracing to the whole brain to examine the LDT cell type specific upstream nuclei. The LDT received very strong midbrain and hindbrain afferents and moderate cortical and hypothalamic innervation but weak connections to the thalamus. The main projection neurons from cortical areas were restricted to the limbic lobe, including the ventral orbital cortex(VO), prelimbic, and cingulate cortices. Although different cell populations received qualitatively similar inputs, primarily via afferents from the periaqueductal gray area, superior colliculus, and the LDT itself, parvalbumin-positive(PV?) GABAergic cells received preferential projections from local LDT neurons.With regard to the different subtypes of GABAergic cells, aconsiderable number of nuclei, including those of the ventral tegmental area, central amygdaloid nucleus, and VO, made significantly greater inputs to somatostatinpositive cells than to PV?cells. Diverse inputs to the LDT on a system-wide level were revealed.

【Keywords】

Laterodorsal tegmentum;;Rabies virus retrograde tracing;;Limbic lobe;;Mice

References

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Total: 9 articles

  • [1] Lingzhong Fan;Tianzi Jiang;Brainnetome Center,Institute of Automation,Chinese Academy of Sciences;University of Chinese Academy of Sciences;National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences;CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Automation,Chinese Academy of Sciences;Key Laboratory for Neuro Information of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China;The Queensland Brain Institute,University of Queensland;, Mapping Underlying Maturational Changes in Human Brain, Neuroscience Bulletin,
  • [2] Yang-Yang Zhang;Lijuan Xu;Zhu-Yuan Liang;Kun Wang;Bing Hou;Yuan Zhou;Shu Li;Tianzi Jiang;School of Psychology, Shaanxi Normal University;Brainnetome Center, Institute of Automation, University of Chinese Academy of Sciences;National Laboratory of Pattern Recognition, Institute of Automation, University of Chinese Academy of Sciences;CAS Key Laboratory of Behavioral Science, Institute of Psychology;Department of Psychology, University of Chinese Academy of Sciences;Department of Psychology and Behavioral Sciences, Zhejiang University;CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences;The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China;, Separate Neural Networks for Gains and Losses in Intertemporal Choice, Neuroscience Bulletin,
  • [3] C.L. Nelson;;J.B. Wetter;;M. Milovanovic;;M.E. Wolf, The laterodorsal tegmentum contributes to behavioral sensitization to amphetamine, Neuroscience,
  • [4] S.A Oakman;;P.L Faris;;C Cozzari;;B.K Hartman, Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups, Neuroscience,

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