Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

【Author】

Yiqiong Liu;Yunong Sun;Xiaoyan Zhao;Ji-Young Kim;Lu Luo;Qian Wang;Xiaolu Meng;Yonghui Li;Nan Sui;Zhou-Feng Chen;Chuxiong Pan;Liang Li;Yan Zhang;State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University;PKU-IDG/Mc Govern Institute for Brain Research;Hendrix College;Department of Anesthesiology, Beijing Tongren Hospital,Capital Medical University;Department of Anesthesiology, Department of Psychiatry,Department of Developmental Biology, Center for the Study of Itch, Washington University School of Medicine;School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University;Key Laboratory of Mental Health, Institute of Psychology,Chinese Academy of Sciences;Beijing Institute for Brain Disorders;

【Institution】

State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University;PKU-IDG/Mc Govern Institute for Brain Research;Hendrix College;Department of Anesthesiology, Beijing Tongren Hospital,Capital Medical University;Department of Anesthesiology, Department of Psychiatry,Department of Developmental Biology, Center for the Study of Itch, Washington University School of Medicine;School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University;Key Laboratory of Mental Health, Institute of Psychology,Chinese Academy of Sciences;Beijing Institute for Brain Disorders;

【Abstract】

Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.

【Keywords】

5-HT;;Aggression;;Social isolation;;Dopamine;;Lmx1b

References

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Total: 49 articles

  • [1] Ning Song;Junxia Xie;Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University;Institute of Brain Science and Disease, Qingdao University;, Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease, Neuroscience Bulletin,
  • [2] ANDan Qian;Xin Wang;Huiru Liu;Jiejie Tao;Jiejie Zhou;Qiong Ye;Jiance Li;Chuang Yang;Jingliang Cheng;Ke Zhao;Meihao Wang;Department of Radiology, First Affiliated Hospital of Wenzhou Medical University;Department of Radiology, Yancheng First People's Hospital;Department of Mental Health, First Affiliated Hospital of Wenzhou Medical University;Department of Radiology, First Affiliated Hospital of Zhengzhou University;Department of Psychiatry, Wenzhou Medical University;, Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study, Neuroscience Bulletin,
  • [3] Liang Li;;Yi Du;;Nanxin Li;;Xihong Wu;;Yanhong Wu, Top–down modulation of prepulse inhibition of the startle reflex in humans and rats, Neuroscience and Biobehavioral Reviews,
  • [4] Alexa H. Veenema, Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: What can we learn from animal models?, Frontiers in Neuroendocrinology,

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