Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses

【Author】

Jiamin Li;Taian Liu;Yun Dong;Kunio Kondoh;Zhonghua Lu;Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences;Japan Science and Technology Agency;

【Institution】

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences;Japan Science and Technology Agency;

【Abstract】

A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. In this paper, we review the recent developments of neurotropic viral tracers and highlight their unique properties in revealing patterns of neuronal connections.

【Keywords】

Neurotropic virus;;Central nervous system;;Neural circuit;;Trans-synaptic tracer;;Retrograde tracing;;Anterograde tracing

References

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