HOTAIR:an oncogenic long non-coding RNA in different cancers

Mohammadreza Hajjari;Abbas Salavaty;Department of Genetics,Faculty of Science,Shahid Chamran University of Ahvaz;

IntroductionThe physiological and developmental complications of humanslead us to the point that the limited number of protein-codinggenes compared w ith w hole genome cannot ex plain thecomplexity of ...

Cytokine-induced killer (ClK) cells:from basic research to clinical translation

Yelei Guo;Weidong Han;Department of Immunology,Institute of Basic Medicine,Chinese PLA General Hospital;

Background Cytokine-induced killer(CIK)cells are a heterogeneous cell population that was first discovered in the 1990s and can be generated from lymphocytes co-culturedwith an anti-CD3 antibody and m ...

Advances in the management of acquired resistance to EGFR-TKI in non-small cell lung cancer

Fei Zhou;Caicun Zhou;Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine;

With the identification of epidermal growth factorreceptor(EGFR)mutations that are correlated with thesensitivity to EGFR-targeted tyrosine kinase inhibitors(EGFR-TKIs)over the past decade[1–2],the de ...

Effect of survivin siRNA on biological behaviour of breast cancer MCF7cells

Hao Wang;Yi-Feng Ye;Sichuan Academy of Medical Sciences,Department of Breast Surgery of Sichuan Provincial People's Hospital;

1.Introduction Breast cancer is a malignant tumor occurred in the mammarygland epithelial tissue,its clinical manifestations is associated withthe stage of tumor.The incidence of breast cancer is incr ...


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