Structure-based design of anti-angiogenic and anti-tumor peptldomimetics targeting gaiectin-1

【Author】

Kevin H.Mayo;

【Abstract】

<正>Galectin-1(gal-1) belongs to a conserved family of lectins with a conserved carbohydrate recognition domain that binds S-galactoside groups on various cell surface receptors.Gal-1 is highly upregulated in tumor-activated endothelial cells,and has been reported in several cancers.We have shown that structure-based design of a peptide 3Smer,anginex,targets gal-1 and inhibits

【Keywords】

DBF;Structure-based design of anti-angiogenic and anti-tumor peptldomimetics targeting gaiectin-1;

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