Sex differences in SARS-CoV-2 infections, anti-viral immunity and vaccine responses

【Author】

Abhishek Mohanty;Aanchal Sawhney;Shefali Gupta;Vishal Rao;Periyasamy Govindaraj;Sambit Mohanty;Vandana Jain;Rajiv Gandhi Cancer Institute and Research Centre;HCG Cancer Hospitals;All India Institute of Medical Sciences;Centre for DNA Finger Printing and Diagnostics;CORE Diagnostics;

【Institution】

Rajiv Gandhi Cancer Institute and Research Centre;HCG Cancer Hospitals;All India Institute of Medical Sciences;Centre for DNA Finger Printing and Diagnostics;CORE Diagnostics;

【Abstract】

The COVID-19 pandemic has revealed sex-based differences in anti-viral responses, with a higher rate of SARS-CoV-2 infections as well as a higher rate of morbidity and mortality in men than in women. Males and females also show disparate immune responses to COVID-19 infection, which may be important contributors to lower rates of infection, disease severity and deaths in women than in men. Here, the authors review sex differences in SARSCoV-2 infections, anti-viral immunity and vaccine responses,putting forth the importance of sex, the underappreciated variables in vaccine response and disease infectivity.

【Keywords】

SARS-CoV-2;;Antiviral immunity;;Sex based mitochondrial differences;;Vaccine responses;;Innate immunity;;Sex differences;;COVID-19 pandemic

References

To explore the background and basis of the node document

Springer Journals Database

Total: 47 articles

  • [1] Anuja Lipsa;Jyothi S Prabhu;St Johns Research Institute and St Johns Medical College, St Johns National Academy of Health Sciences;, Gender disparity in COVID-19: Role of sex steroid hormones, Asian Pacific Journal of Tropical Medicine,
  • [2] Franceschi C;;Bonafè M;;Valensin S;;Olivieri F;;De Luca M;;Ottaviani E;;De Benedictis G, Inflamm-aging. An evolutionary perspective on immunosenescence., Annals of the New York Academy of Sciences,
  • [3] Li Wenhui;;Zhang Chengsheng;;Sui Jianhua;;Kuhn Jens H;;Moore Michael J;;Luo Shiwen;;Wong Swee-Kee;;Huang I-Chueh;;Xu Keming;;Vasilieva Natalya;;Murakami Akikazu;;He Yaqing;;Marasco Wayne A;;Guan Yi;;Choe Hyeryun;;Farzan Michael, Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2., The EMBO journal,
  • [4] Sui Jianhua;;Li Wenhui;;Murakami Akikazu;;Tamin Azaibi;;Matthews Leslie J;;Wong Swee Kee;;Moore Michael J;;Tallarico Aimee St Clair;;Olurinde Mobolaji;;Choe Hyeryun;;Anderson Larry J;;Bellini William J;;Farzan Michael;;Marasco Wayne A, Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association., Proceedings of the National Academy of Sciences of the United States of America,

More>>

Similar documents

Documents that have the similar content to the node document

  • [1] Comparison of antileukemic immunity mediated by dendritic cells derived from multidrug resistant leukemia K562/A02 cells and sensitive K562 cells, Chinese Medical Journal, 2005 (07)
  • [2] Marie C Lin;Nikki P Lee;Oscar G Wong;Hsiang-Fu Kung;Chee-Kin Hui;John M Luk;George Ka-Kit Lau;, Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus, World Journal of Gastroenterology, 2005 (48)
  • [3] Allegy and Immunology Immunity, China Medical Abstracts(Internal Medicine), 2007 (04)
  • [4] 6.3.Immunity, China Medical Abstracts, 1992 (01)

More>>