IOP lowering effect of losartan and latanoprost in oculohypertensive rats:A comparative evaluation

【Author】

Siti Nur Laili MOHAMED;Tajui Atiqah ZAULKAFALI;Renu AGARWAL;Anna KRASILNIKOVA;Nafeeza ISMAIL;

【Abstract】

<正>Aim:To evaluate the intraocular pressure(IOP) lowering effect of losartan potassium in rats with steroid-induced ocular hypertension and compare the IOP lowering effects with that of latanoprost.Methods:Ocular hypertension was induced in Sprague Dawley rats weighing 100 to 120 g by topical application of 5μL dexamethasone 0.1%twice daily for 36 d.Rats with IOP increment of 25%or more from baseline were used for further study and were divided into 2 groups(n=7). Following baseline IOP estimation single drop(10 uL) of losartan 2%in group 1 or

【Keywords】

IOP;;steroid-induced;;rats;;losartan;;latanoprost

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